Interferon Signaling and the Differential Malignancy Spectrum of Down Syndrome

Summary

Serving the catchment area of the State of Colorado, UCCC, a matrix within the School of Medicine, is a multidisciplinary research consortium of the University of Colorado at Denver and Boulder, Colorado State University and clinical affiliates University of Colorado Hospital, Children's Hospital Colorado and the Denver VA. The UCCC achieves its mission to discover, develop, and deliver breakthroughs in cancer science through interdisciplinary collaborative research.

Down Syndrome Publications

PloS one2021

Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity.

Blood advances2021

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation.

Cell reports2020

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.

Proceedings of the National Academy of Sciences of the United States of America2019

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.

Summary​

Down Syndrome Publications​

Summary

Down Syndrome Publications