grants

Administrative Supplement to the CHARGE Study (Childhood Autism Risks from Genetics and the Environment)

Hertz Picciotto, Irva

Summary​

This project addresses Down Syndrome, the most common cause of low mental functioning. It focuses on the biologic and environmental factors that may account for the deficits in mental function and the associated health problems, and thereby addresses an important public health issue.

Down Syndrome Publications​

Epigenetics & chromatin2021
Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.
Human molecular genetics2021
Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profiles.
Translational psychiatry2019
Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.