Summary
Hypoxia is defined as an inadequate O2 supply to whole body or a region of body. Hypoxia is a dangerous condition for both normal individuals under high altitude hypoxia and patients with chronic renal disease, respiratory and hemolytic diseases. However, current strategies to counteract physiological and pathological hypoxia are limited due to a lack of fundamental understanding of the molecular mechanisms underlying adaptation to hypoxia. Research proposed here is based on our novel and compelling findings revealing that plasma adenosine are elevated to promote erythrocyte metabolic changes and trigger oxygen delivery to adapt to high altitude and counteract renal hypoxia, kidney damage and disease progression in chronic kidney disease (CKD). The proposed studies are extremely innovative since the functional role of adenosine mediated-oxygen delivery from red blood cells in CKD had not been previously recognized. The impact of proposed research is highly significant since it is likely to provide innovative therapies in CKD and even in any condition involving hypoxia.
Down Syndrome Publications
Nature communications2019