Lifestyle and Alzheimer's Disease In Down Syndrome

Hartley, Sigan L

Summary​

Adults with Down syndrome experience an early age of onset and increased risk for Alzheimer's disease. The proposed study addresses this public health crisis and advances science by providing the first longitudinal investigation of the effect of four lifestyle factors (physical activity, sleep, cognitive stimulation, and social engagement) on the age of onset of early Alzheimer's neurodegeneration and on the timing of the transition to clinical dementia in adults with Down syndrome. These lifestyle factors may be important modifiable resiliency mechanisms for delaying Alzheimer's disease in adults with Down syndrome despite their genetic risk.

Down Syndrome Publications​