Altered Hippocampal Neurogenesis and Cognition via Maneb-mediated Changes in the Thiol Redox Proteome.

Roede, James R


Down syndrome, a genetic condition resulting in the triplication of chromosome 21, occurs in 1 in approximately 700 live births in the United States of America. We believe that, due to this genetic condition, Down syndrome patients are more vulnerable to toxic chemicals in the environment, and that these exposures contribute to the variability of intellectual disability observed in this patient population. This project is designed to test this hypothesis.