Belkind Gerson, JaimeFrank, Daniel NSullivan, Kelly D
Summary
Individuals with Down syndrome are predisposed to a wide range of co-occurring conditions, including many gastrointestinal conditions. This proposal will test the hypothesis that innate alterations in inflammation, metabolism, and the microbiome result in enteric nervous system dysfunction that drives these conditions. Insights from these studies could not only increase our understanding of gastrointestinal disease in Down syndrome, but also identify new therapeutic strategies for their management.