Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Thomas, Jared RSloan, KourtneyCave, KelseyWallace, Joseph MRoper, Randall J


Those with Down syndrome (DS) experience decreased bone mass, shortened height and weaker bones. Research has shown that there is a sexual dimorphism at play when it comes to the bone mineral density (BMD), with males experiencing earlier losses of BMD than females. The gene thought to be associated with these skeletal effects is called DYRK1A. This research suggests that skeletal deficits in DS mouse models used in this work are sex and age dependent. However, these observations are not solely caused by the overexpression of DYRK1A in osteoblasts and more research is needed.