Summary
People with Down Syndrome (Trisomy 21) often have multiple ocular issues, including cataracts. Increase in phosphorylated forms of Tau are caused by kinases encoded on chromosome 21, causing tauopathy in the eye (retina and lens). We propose to adapt our technology platform to discover nanobodies to A in our parent grant to discover nanobodies as probes and use them to detect, and characterize relevant tau forms in the eye, improving health and preventing such degeneration for people with Down Syndrome.