researchers

Chang, Geoffrey A PHD

University of California, San Diego

INCLUDE Grants

Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers

Chang, Geoffrey A

People with Down Syndrome (Trisomy 21) often have multiple ocular issues, including cataracts. Increase in phosphorylated forms of Tau are caused by kinases encoded on chromosome 21, causing tauopathy in the eye (retina and lens). We propose to adapt our technology platform to discover nanobodies to A in our parent grant to discover nanobodies as probes and use them to detect, and characterize relevant tau forms in the eye, improving health and preventing such degeneration for people with Down Syndrome.

Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers

Chang, Geoffrey A

People with Down Syndrome (Trisomy 21) often have multiple ocular issues, including cataracts. Beta-amyloid and its aggregates, which are derived from a cleavage product of a protein located on Chromosome 21, accumulate in the eye (retina and lens). We propose to use an in-house technology to discover nanobodies that can be used as probes to detect, characterize, and potentially sequester/dissolve beta-amyloid in the eye, improving health and preventing such degeneration for people with Down Syndrome.