ABC-DS MOMs’ Supplement (Modification of Maternal AD risk in DS)

Christian, Bradley THanden, Benjamin LHead, ElizabethMapstone, Mark


Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome (DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. This proposed pilot project will focus on parents of adults with DS, allowing us to address important questions related to the potential impact of a range of genetic factors on both maternal AD risk and AD risk to their DS offspring.