Handen, Benjamin LPrice, Julie C
Summary
This research is highly relevant to the goals and priorities of both the parent ABC-DS grant (U19 AG068054, “Alzheimer Biomarker Consortium – Down Syndrome”) and the INCLUDE project. We will develop a multivariate multimodal analysis framework to better leverage the complexity and richness of multimodal neuroimaging datasets and provide improved spatiotemporal mapping of Aβ and tau accumulation (baseline and longitudinal)in DS. This will enable more sensitive detection of early and progressive pathophysiological changes in DS, relative to prior assessments. The analysis platform will be shared to promote novel multimodal hypothesis development and testing.