INCLUDE Grants​

Imaging of Mitochondial Complex I function in Down Syndrome

Price, Julie CRosas, Herminia Diana

Alterations in mitochondrial ATP production and redox homeostasis in brain mitochondria are strongly associated with pathogenesis in Down syndrome (DS) and Alzheimer disease. We propose to optimize [18F]-BCPP-EF PET imaging for the robust assessment of Mitochondrial Complex I function in living individuals with DS and for whom alterations in mitochondrial bioenergetics are well established, with an overall goal of providing new in vivo information that contributes new knowledge about the risk for AD in people with DS.

Supplement to: Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)

Handen, Benjamin LPrice, Julie C

This research is highly relevant to the goals and priorities of both the parent ABC-DS grant (U19 AG068054, “Alzheimer Biomarker Consortium – Down Syndrome”) and the INCLUDE project. We will develop a multivariate multimodal analysis framework to better leverage the complexity and richness of multimodal neuroimaging datasets and provide improved spatiotemporal mapping of Aβ and tau accumulation (baseline and longitudinal)in DS. This will enable more sensitive detection of early and progressive pathophysiological changes in DS, relative to prior assessments. The analysis platform will be shared to promote novel multimodal hypothesis development and testing.