Development of Executive Function Measures for Clinical Trials in Down Syndrome

Fatemi, S AliSchlaggar, Bradley L

Summary​

The goal of this project, entitled “Validation of a Behavioral Measure of Executive Function as a Resource to Support Preparedness for Clinical Trials in Down Syndrome” is to develop and distribute resources for use by the broader scientific community, intended for furthering research and increasing preparedness for clinical trials in individuals with Down syndrome (DS). There is a key need for assessment tools that are ecologically valid for assessing key neurobehavioral functions in DS, and in delineating outcomes for behavioral and pharmacological clinical trials. Specifically, the study will develop and distribute a dataset of caregiver ratings of EF in 1000 individuals (ages 8-25 years) with DS and will deliver the distributions and item-level dataset itself, which will be shared in DS-Connect®, along with data on reliability (temporal stability), construct utility, and item utility for use by investigators in future clinical trials.

Down Syndrome Publications​