Silverman, WayneKrinsky-McHale, Sharon JLai, FlorenceDiana Rosas, HHom, ChristyDoran, EricPulsifer, MargaretLott, IraSchupf, Nicole
Summary
The National Task Group-Early Detection Screen for Dementia (NTG-EDSD) is a tool for evaluating dementia status, including Down syndrome (DS) with mild cognitive impairment (MCI-DS). In this study, the accuracy of the NTG-EDSD was evaluated in a sample of 185 adults with MCI-DS. Results indicated that sections of the NTG-EDSD such as ‘Memory’ and ‘Language and Communication’ were sensitive to MCI-DS. However, the sensitivity and specificity of the NTG-EDSD needs adjustment in most other areas in order for it to be accepted as an accurate screening overall.
Abstract
The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing 'mild cognitive impairment (MCI-DS)'. Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the 'Memory' or 'Language and Communication' domains being most informative. The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.
Conditions
Alzheimer Disease, Cognitive Dysfunction, Dementia, Disease Progression, Intellectual Disability, Mild Cognitive Impairment