Summary
Type I Interferons (IFNs) are important in infection and inflammation. The purpose of this study is to delineate the role of key regulators of IFN response, ISG15 and USP18, via the study of rare ISG15 deficient and USP18 deficient humans. Improved understanding of how ISG15 and USP18 regulate IFN-mediated immune responses will inform the design of both anti-inflammatory and anti-infective therapeutics.