Bogunovic, Dusan PHD

Icahn School of Medicine


Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies

Bogunovic, Dusan

Type I Interferons (IFNs) are important in infection and inflammation. The purpose of this study is to delineate the role of key regulators of IFN response, ISG15 and USP18, via the study of rare ISG15 deficient and USP18 deficient humans. Improved understanding of how ISG15 and USP18 regulate IFN-mediated immune responses will inform the design of both anti-inflammatory and anti-infective therapeutics.    

Role of SARS-CoV-2-mediated Type I IFN antagonism in individuals with Down Syndrome

Bogunovic, Dusan

Down syndrome is principally caused by trisomy of chromosome 21, resulting in extra copies of the interferon receptors, IFNAR1 and IFNAR2. Signaling through these IFN receptors to initiates the highly potent antiviral and inflammatory functions of the type I Interferons (IFNs) response. The purpose of this study is to understand how altered IFN receptor availability, as is the case in Downs syndrome individuals, impact the SARS-CoV-2 pathogenesis.

Down Syndrome Publications

Genetics in medicine : official journal of the American College of Medical Genetics2021
Journal of clinical immunology2020