Summary
While survival in individuals with Down syndrome (DS) has improved greatly, multiple co-occurring conditions jeopardize quality of life and threaten life expectancy. Limited research examining either the natural history or the underpinnings of these comorbidities is available for informing screening practices and therapeutic interventions. This proposal will study the occurrence and emergence of multiple co-morbidities as well as ethical issues and social determinants of health affecting a diverse group of infants, youth, and young adults with DS.