researchers

Barrett, Lindy Elise PHD

Broad Institute of MIT and Harvard

INCLUDE Grants

Dissecting the role of FMRP in RNA processing using hPSC models

Barrett, Lindy Elise

The goal of this proposal is to elucidate fundamental molecular mechanisms of the RNA binding protein FMRP in relevant human cell types. Our preliminary data show that FMRP binds pre-mRNA targets in human embryonic stem cells and excitatory cortical neurons, and we will now test as series of hypotheses regarding FMRP’s role in RNA processing. As loss of FMRP is causative for Fragile X syndrome, these data have important implications for human disease biology.