researchers

Blanco, Javier Guillermo PHD

University at Buffalo

INCLUDE Grants​

Evaluation of myocardial targets to prevent anthracycline cardiotoxicity in children with Down Syndrome and Leukemia

Blanco, Javier Guillermo

Children with Down syndrome (DS) and acute myeloid leukemia (AML) are highly susceptible to anthracycline- related cardiotoxicity. This project will delineate the contribution of specific molecular factors to anthracycline- cardiotoxicity in the DS setting. Results of these integrative studies will provide new data for the design of novel pharmacological interventions to prevent the development of cardiotoxicity in children with DS and AML.

Down Syndrome Publications​

Scientific reports2021
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21).
Gene2021
Comparative genome-wide DNA methylation analysis in myocardial tissue from donors with and without Down syndrome.