Role of midlife cardiovascular disease on Alzheimer’s Pathology and cerebrovascular reactivity in the young-old.

Cohen, Ann D

Alzheimer's disease (AD) and cardiovascular disease (CaVD) are two of the most common disorders of aging, understanding the relationship between the pathologies of these two disorders is critically important. The goal of this study is to further the understanding of the relationship between AD pathology and midlife CaVD. We will utilize a group 80 participants with a wealth of existing CaVD data from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with 2000 participants (43% black) between the ages of 45-75 years. Our goal is to understand how CaVD and AD pathology interact to produce cognitive changes in the elderly.