INCLUDE Grants​

Mechanisms of Leukemogenesis in Down Syndrome

Crispino, John D

Children with Down syndrome, who have three copies of chromosome 21, face a 500-fold increased risk of developing acute megakaryoblastic leukemia and a 20-fold increased risk of pre-B cell acute lymphoblastic leukemia. Our research will uncover the mechanisms by which three copies of two genes on chromosome 21, the kinase DYRK1A and the chromatin assembly factor CHAF1B, contribute to normal and malignant hematopoiesis. Our work will also aid in the development of new, targeted therapies for these leukemias.

Down Syndrome Publications​

Leukemia2021
Clinical and biological aspects of myeloid leukemia in Down syndrome.
The Journal of clinical investigation2021
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3
Clinical cancer research : an official journal of the American Association for Cancer Research2020
Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Cold Spring Harbor perspectives in medicine2020
Acute Megakaryocytic Leukemia.