Jiang, Peng PHD
RUTGERS, THE STATE UNIV OF N.J.
INCLUDE Grants
A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down Syndrome
Down syndrome (DS), caused by triplication of human chromosome 21, is the single most common risk factor for Alzheimer’s disease (AD) and people with DS typically develop early-onset AD and dementia by their 60s. Here, we propose to employ a novel human microglial chimeric mouse brain model that is created by transplantation of human DS induced pluripotent stem cell-derived microglia to study the role of human microglia in AD/DS in vivo. Results from this study will help us better understand the mechanisms underlying the AD in DS and may steer AD therapeutic interventions into a new direction of aiming at preventing microglial senescence or rejuvenating microglia.