Redline, Susan S MPH
Brigham and Women's Hospital
INCLUDE Grants
Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea
Pediatric OSA is highly prevalent in children with Down Syndrome, leading to significant morbidity if not accurately diagnosed or treated. Oxygen saturation measurement with pulse oximetry is critical in diagnosing obstructive sleep apnea (OSA) by polysomnography; however, growing data suggest that oximetry may underestimate hypoxemia in darkly pigmented skin, resulting in under-diagnosis and under-treatment. Therefore, understanding potential oximetry-related biases is vital in ensuring equitable diagnosis and treatment of OSA in high-risk children from diverse populations, including children with Down Syndrome. We propose to investigate to what extent oximetry-related biases impact the diagnosis and severity of OSA in children with Down Syndrome.
Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea
A large percentage of children with Down Syndrome (DS) have obstructive sleep apnea (OSA) that is suboptimally treated by first-line surgical interventions. The persistence of OSA-related nightly intermittent hypoxemia and fragmented sleep may contribute to a cognitive impairment, reduced daily functional impairment as well as pulmonary vascular disease and myocardial dysfunction. We propose a randomized trial of oxygen therapy to treat obstructive sleep apnea.