grants

The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-Revision

Busciglio, Jorge AFortea, Juan

Summary​

Down syndrome (DS) is an outstanding natural genetic model for the study of neuropathological mechanisms of Alzheimer´s disease (AD) and for identifying potential AD biomarkers. The study of the Alzheimer's preclinical phase is crucial for the development of new future treatments that could eventually slow down or stop the progression of the disease before any cognitive decline. This competing revision application will provide additional biochemical biomarkers of neurodegeneration and oxidative stress, as well as neuroimaging studies in our well-characterized cohort which will significantly expand the relevance and impact of the original parent RO1.!

Down Syndrome Publications​

The Lancet. Neurology2021
Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study
Nature communications2021
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome.
Alzheimer's & dementia : the journal of the Alzheimer's Association2021
Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study.
Journal of Alzheimer's disease : JAD2021
The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation.