Fortea, Juan MD

INCLUDE Grants​

Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study

Blessing, Esther MarianFortea, Juan

Down syndrome (DS), the most frequent cause of intellectual disability and the most frequent form of Alzheimer´s disease (AD) of genetic origin, involves an ultra-high risk for developing AD (>95% in the seventh decade). While the age of AD onset in people with DS is on average ~20–30 years younger than in sporadic AD, there is considerable heterogeneity, with some individuals developing AD later in life. This project focuses on sleep disturbance and impaired circadian thermoregulation as potentially modifiable risk factors for AD, which may lead to interventions to delay AD onset in people with DS.

The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-Revision

Busciglio, Jorge AFortea, Juan

Down syndrome (DS) is an outstanding natural genetic model for the study of neuropathological mechanisms of Alzheimer´s disease (AD) and for identifying potential AD biomarkers. The study of the Alzheimer's preclinical phase is crucial for the development of new future treatments that could eventually slow down or stop the progression of the disease before any cognitive decline. This competing revision application will provide additional biochemical biomarkers of neurodegeneration and oxidative stress, as well as neuroimaging studies in our well-characterized cohort which will significantly expand the relevance and impact of the original parent RO1.!

Down Syndrome Publications​