Busciglio, Jorge A PHD

University of California, Irvine


The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-Revision

Busciglio, Jorge AFortea, Juan

Down syndrome (DS) is an outstanding natural genetic model for the study of neuropathological mechanisms of Alzheimer´s disease (AD) and for identifying potential AD biomarkers. The study of the Alzheimer's preclinical phase is crucial for the development of new future treatments that could eventually slow down or stop the progression of the disease before any cognitive decline. This competing revision application will provide additional biochemical biomarkers of neurodegeneration and oxidative stress, as well as neuroimaging studies in our well-characterized cohort which will significantly expand the relevance and impact of the original parent RO1.!

Down Syndrome Publications