Bhattacharyya, Anita PHD
University of Wisconsin, Madison
As the most common genetic cause of intellectual disability, Down syndrome is a public health concern. The proposed research will create new models of Down syndrome to advance the study of Down syndrome neuropathophysiology. The aims of this proposal include generating Down syndrome-specific human pluripotent stem cells from non-embryonic sources.
As the most common genetic developmental disorder that leads to intellectual disability, Down syndrome is a public health concern. The proposed research will better define the developmental defects that occur during formation of the human brain in Down syndrome. The results will provide insight into the biological bases of intellectual and developmental disabilities and could potentially lead to the design of therapeutic interventions.