Combs, Daniel MD
University of Arizona
INCLUDE Grants
DEtermining Capacity and Informing Down syndrome Assent Strategies (DECIDAS)
Assent is required for most children and adults with intellectual disabilities, including individuals with Down syndrome, to participate in clinical trials. However, the capacity (ability to understand information and make an appropriate choice) to assent in people with Down syndrome is unknown; given that Down syndrome is associated with cognitive impairment, it is likely that many individuals with Down syndrome do not have capacity to provide assent. This project will determine the capacity of individuals with Down syndrome to provide assent as well as determine the assent-related preferences of parents/legally authorized representatives of children and adults with Down syndrome.
Medications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS)
Obstructive sleep apnea is common in children with Down syndrome and current treatments such as adenotonsillectomy and positive airway pressure therapy have limited effectiveness in children with Down syndrome. This project will evaluate the combination of two medications, atomoxetine and oxybutynin, as a treatment for obstructive sleep apnea in children with Down syndrome. Effective obstructive sleep apnea therapy with these medications may lead to improved quality of life and cognition in children with Down syndrome.