Espinosa, Joaquin M PHD

University of Colorado Denver


A Pilot for Enhancing Support for a Federated Framework of Biospecimens for Down Syndrome Research via the INCLUDE Data Hub

Espinosa, Joaquin MResnick, Adam Cain

The respective biorepositories of the Children’s Hospital of Philadelphia and the Crnic Institute Human Trisome Project Biobank will partner with the INCLUDE Data Hub to support the proposed development of a centralized biorepository data resource to coordinate a single biospecimen data repository or a network of repositories curating and distributing tissue specimens, cell lines, and associated derived analytes such as DNA, RNA, metabolites or proteins relevant to Down syndrome research. Coordinating the linkages between samples, clinical data, and derived biosample characterization data and/files such that a federated framework of queryable samples are available as an integrated resource to the investigator community remains a fundamental challenge. This project will address this unmet need in the field.

DCC supplement for Experimental Models Portal and Enhanced Security

DiGiovanna, JackEspinosa, Joaquin MO'Connor, BrianResnick, Adam Cain

This is a proposal to support the design of a pilot data portal for sharing and analysis of data from experimental models of Down syndrome, and to enhance the security ecosystem of the existing researcher portal known as the INCLUDE Data Hub. The activities supported by this award will enable the future creation of an Experimental Models Portal within the INCLUDE Data Hub, while also supporting full compliance with advanced security standards.

Down Syndrome Publications